Next generation sequencing is a laboratory method that has been developed to sequence DNA. Whole-genome sequencing has already transformed how scientists study the human genome. The increased amount of data available on the human genome has led to further progress in medicine, pharmacogenomics and personalized medicine. Because of its high throughput, precise and abundant information about the genome, it can be used for many other applications.
Why you need next generation sequencing
1. It produces a lot of data
The key point of next generation sequencing is speed. How much data can be generated in a relatively short period of time. It has been said that: 'a million base pair genome can be sequenced in a day'. Although it is an exaggeration, the rate of production will make traditional sequencing machines pale in comparison.
2. It is cheap
Cost saving is the second important aspect of NGS. The rate of producing data from NGS machines are at least 1000 times cheaper than that from Sanger sequencers. Therefore next generation sequencing have become more and more popular among genetic researchers.
3. It is accurate and reliable
The machine can more accurately sequence the genome of the organism. The accuracy of process is from 99.9% to 100%. The second important point is that it is relatively fault-free: no extra bases are added during the sequencing process, which makes it more reliable.
4. It can discover other genes related to disease
Since NGS machines can sequence genes very fast and in a high throughput, it has established a new way for pharmacogenomics research and personalized medicine. Now, researchers can easily search for other genes related to diseases through sequencing, like cancer and Alzheimer's disease. The process have already been applied on several organisms directly in the field of medicine.
In conclusion, NGS is a method that can produce a lot of data in a relatively short period of time, it is very useful for many different applications such as pharmacogenomics and personalized medicine. Another important factor that integrates with its high accuracy, reliable and low cost is the future application of its machine.
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